Zheng Chen

FBXL21 regulates diurnal proteostasis and stress response by targeting DNAJB6 and client proteins

This study identifies FBXL21 as a circadian E3 ligase that regulates proteostasis and stress response by targeting DNAJB6 and its client proteins, with implications for myopathies.

DHHC3-dependent S-Acylation of CRY1 regulates its subcellular localization and repressor function in the circadian clock

This study identifies S-acylation of CRY1 as a critical post-translational modification regulated by DHHC3, essential for its nuclear localization and repressor function in the circadian clock.

Cryptochrome Loss Drives COPD-like Lung Pathology through Disrupted Alveolar Epithelial Proliferation and Immune Homeostasis

This study shows that loss of Cryptochrome 1 and 2 leads to COPD-like lung disease through disrupted epithelial proliferation and immune homeostasis, and that Nobiletin can alleviate these effects.

Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a NO-CCL2-CCR2 pathway

This study identifies Slc4a4's role in maintaining blood-brain barrier integrity through the NO-CCL2-CCR2 pathway in astrocytes, showing its importance in both healthy and stroke conditions.

A novel bioinformatics approach to reveal the role of circadian oscillations in AD development

This study introduces ESOCVD, a computational platform to detect circadian gene expression patterns in AD using untimed transcriptome data, revealing five circadian alteration patterns in AD patients.

Tissue-specific BMAL1 cistromes reveal that enhancer-enhancer interactions regulate rhythmic transcription

The paper shows BMAL1 DNA binding is tissue-specific and regulates rhythmic transcription through enhancer-enhancer interactions in the mouse liver.