Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates
Jennifer N. Wells, Lucy V. Edwardes, Vera Leber, Shenaz Allyjaun, Matthew Peach, Joshua Tomkins, Antonia Kefala Stavridi, Sarah V. Faull, Ricardo J. Aramayo, C. M. Pestana, Lepakshi Ranjha, Christian Speck
This study reconstitutes human DNA licensing, analyzes its intermediates, and identifies how cancer mutations disrupt helicase loading.
Nature Communications · Jan 8, 2025Peer-reviewedBiochemistry