Author

Christian Speck

MRC London Institute of Medical SciencesORCID 0000-0001-6646-1692Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Mohammad Mahdi KarimiiD· 2 shared Aida Di Gregorio· 1 shared Alex MontoyaiD· 1 shared Ammar Tareen· 1 shared Antonia Kefala Stavridi· 1 shared Audrey MossleriD· 1 shared Benjamin Moyon· 1 shared Bruce StillmaniD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersMolecular Biology

Mohammad Mahdi KarimiORCID

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4 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedJul 23, 2026

Mechanisms of MCM2-7 helicase activation and initial DNA melting at near base-pair resolution

Chris Weekes, Lia Willerding, Sanjay P. Khadayate…·L. Reuter

The paper identifies a DNA-bound intermediate during MCM2-7 helicase activation and shows how DNA unwinding is coupled to helicase complex disassembly and DNA exit.

3 citationstop 3%

DNA methylationproteomics

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BiochemistryNature CommunicationsPeer-reviewedJan 8, 2025

Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates

Jennifer N. Wells, Lucy V. Edwardes, Vera Leber…·Christian Speck

This study reconstitutes human DNA licensing, analyzes its intermediates, and identifies how cancer mutations disrupt helicase loading.

20 citationstop 5%

humanstructural biology

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Molecular BiologyNature CommunicationsPeer-reviewedOct 14, 2020

Evolution of DNA Replication Origin Specification and Gene Silencing Mechanisms

Yixin Hu, Ammar Tareen, Yi-Jun Sheu…·Bruce Stillman

The paper identifies sequence-specificity in DNA replication origins mediated by Orc4 α-helix in S. cerevisiae and links its evolution to gene silencing mechanisms.

37 citations

yeastDNA methylation

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Developmental BiologyMolecular Biology and EvolutionPeer-reviewedMar 3, 2020

Evolution of an amniote-specific mechanism for modulating ubiquitin signalling via phosphoregulation of the E2 enzyme UBE2D3

Mónica Román-Trufero, Constance M Ito, Conrado Pedebos…·Niall Dillon

The paper identifies a conserved serine in UBE2D3 that, when phosphorylated by Aurora B, reduces UBE2D3 levels and affects early embryonic development in mice.

3 citations

mouseprotein sequence

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