Author

Lepakshi Ranjha

Institute for Research in BiomedicineORCID 0009-0004-7339-5207Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:structural biology· 1 Organism:yeast· 1

Frequent Co-Authors

Céline Adam· 2 shared Damarys LoewiD· 2 shared Petr ĆejkaiD· 2 shared Raphaël GuéroisiD· 2 shared Valérie BordeiD· 2 shared Alba GuarnéiD· 1 shared Alex MontoyaiD· 1 shared Antonia Kefala Stavridi· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersMolecular Biology

Céline Adam

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Author profile →

4 papers

Recent·Most cited

Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates

Jennifer N. Wells, Lucy V. Edwardes, Vera Leber, Shenaz Allyjaun, Matthew Peach, Joshua Tomkins, Antonia Kefala Stavridi, Sarah V. Faull, Ricardo J. Aramayo, C. M. Pestana, Lepakshi Ranjha, Christian Speck

This study reconstitutes human DNA licensing, analyzes its intermediates, and identifies how cancer mutations disrupt helicase loading.

Nature Communications · Jan 8, 2025Peer-reviewedBiochemistry

The Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length

Dipti Vinayak Vernekar, Giordano Reginato, Céline Adam, Lepakshi Ranjha, Florent Dingli, Marie‐Claude Marsolier‐Kergoat, Damarys Loew, Raphaël Guérois, Bertrand Llorente, Petr Ćejka, Valérie Borde

The paper shows that the Pif1 helicase is inhibited by the Mer3-MutLβ complex during meiotic recombination, limiting gene conversion tract length.

Nucleic Acids Research · Mar 22, 2021Peer-reviewedMolecular Biology

Mechanism of in vivo activation of the MutLγ-Exo1 complex for meiotic crossover formation

Aurore Sanchez, Céline Adam, Felix Rauh, Yann Duroc, Lepakshi Ranjha, Bérangère Lombard, Xiaojing Mu, Mélody Wintrebert, Damarys Loew, Alba Guarné, Stefano Gnan, Chun-Long Chen, Scott Keeney, Petr Ćejka, Raphaël Guérois, , Valérie Borde

The paper identifies the role of the MutLγ-Exo1 complex in meiotic crossover formation by showing Exo1 recruits Cdc5 to activate MutLγ and highlights its spatial regulation near DSB hotspots.

Proceedings of the National Academy of Sciences · Nov 16, 2020Peer-reviewedMolecular Biology

The human SKI complex prevents DNA-RNA hybrid-associated telomere instability

Emilia Herrera‐Moyano, Rosa María Porreca, Lepakshi Ranjha, Eleni Skourti, Roser Gonzalez-Franco, Ying Sun, Emmanouil Stylianakis, Alex Montoya, Holger Kramer, Jean‐Baptiste Vannier

This study shows the human SKI complex prevents telomere instability by resolving DNA-RNA hybrids at telomeres during G2 phase.

bioRxiv · May 20, 2020 · PreprintMolecular Biology