DNA origami vaccines program antigen-focused germinal centers
Anna M. Romanov, Grant A. Knappe, Larance Ronsard, Christopher A. Cottrell, Yiming J. Zhang, Heikyung Suh, Lauren Duhamel, Marjan Omer, Asheley Poole Chapman, Katie Spivakovsky, Patrick D. Skog, Claudia T. Flynn, Jeong Hyun Lee, Oleksandr Kalyuzhniy, Alessia Liguori, , Darrell J. Irvine
DNA origami particles displaying eOD-GT8 with a synthetic T helper epitope gave antigen-focused germinal centers and expanded VRC01-class precursors in humanized mice after one immunization.
Science · Feb 5, 2026Peer-reviewedImmunology✦ In-depth digest