Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium
Oscar Pellón-Cárdenas, P Rout, S Hassan, E Fokas, He Ping, I Patel, J Patel, O Plotsker, A Wu, R Kumar, M Akther, A Logerfo, S Wu, Daniel E. Wagner, Dario Boffelli, , MP Verzi
The paper shows Pdgfra+ fibroblasts reprogram during WNT-driven oncogenesis to promote a regenerative state in the epithelium, facilitating tumor formation.
bioRxiv · Jan 22, 2025 · PreprintCancer Biology