Daniel E. Wagner

Spatially restricted bmp16 in an extra-embryonic syncytium promotes dorsoventral patterning

The paper identifies bmp16 expression in the zebrafish yolk syncytial layer and shows its role in dorsoventral patterning through functional perturbations.

Intracellular pH dynamics promotes zebrafish larval tail regeneration

The paper investigates the role of intracellular pH dynamics in zebrafish larval tail regeneration, finding that pH changes are critical for cell proliferation and tissue repair.

BMP signaling during gastrulation pre-patterns the dorsal spinal cord

This study shows that BMP signaling during gastrulation pre-patterns dorsal spinal cord fates, challenging the classic model that attributes this to roofplate-derived BMP.

Dynamic polyadenylation safeguards developmental trajectories during paused embryogenesis

The paper shows that polyadenylation safeguards developmental trajectories during paused embryogenesis in zebrafish by stabilizing mRNA targets and maintaining axial patterning.

ZMAP: A single-cell meta-atlas of zebrafish embryonic development reveals a consensus hierarchy of cell identities

ZMAP integrates multiple zebrafish scRNA-seq datasets to create a harmonized reference atlas, identifying consensus cell identities across studies.

Comprehensive profiling of migratory primordial germ cells reveals niche-specific differences in non-canonical Wnt and Nodal-Lefty signaling in anterior vs posterior migrants

This study profiles mouse migratory primordial germ cells and their niches to show position-specific differences in non-canonical Wnt and Nodal-Lefty signaling during migration.

Two parallel lineage-committed progenitors contribute to the developing brain

The paper identifies two lineage-committed progenitors in the developing brain that generate forebrain/midbrain and hindbrain regions, and demonstrates their distinct chromatin landscapes and differentiation potential.

Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium

The paper shows Pdgfra+ fibroblasts reprogram during WNT-driven oncogenesis to promote a regenerative state in the epithelium, facilitating tumor formation.

Neural plate morphogenesis and pre-patterning enable specification of intermediate progenitors in the spinal cord

The paper shows intermediate spinal cord progenitors are specified through neural plate dynamics and signaling, not direct morphogen exposure.

In vitro characterization of the human segmentation clock

The paper identifies a human segmentation clock by showing human PSM cells exhibit Notch and YAP-dependent oscillations of HES7 with a 5-hour period.

Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain by scGESTALT

The paper introduces scGESTALT, a method that combines single-cell RNA sequencing with lineage tracking to identify cell types and their developmental relationships in the zebrafish brain.