Unraveling the Dual Immunomodulatory and Immunogenic Roles of the Central Conserved Cysteine-Rich Region in Respiratory Syncytial Virus G Protein
Juan Gutman, Ana Luz Paletta, Federico Birnberg-Weiss, Cecilia Arahí Prato, Analia Boudgouste, Carla Jimena Goldin, Santiago Sastre, Alana B. Byrne, Pablo Pakciarz, Fernando P. Polack, Julia Dvorkin, Ari Zeida, Mauricio Tomas Caballero, Verónica Inés Landoni, Gabriela Cristina Fernández, , Sebastián Esperante
This paper investigates how the redox state of the RSV G protein's central conserved cysteine-rich domain (CCD) influences its immunomodulatory and immunogenic properties, showing that monomeric forms suppress immune activation while oligomerization removes this effect.
Frontiers in Microbiology · Mar 11, 2026Peer-reviewedImmunology