Author

Santiago Sastre

Universidad de la República de UruguayORCID 0000-0001-8801-3946Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Ari ZeidaiD· 2 shared Alana B. ByrneiD· 1 shared Ana Luz PalettaiD· 1 shared Analia Boudgouste· 1 shared C DieziD· 1 shared Carla Jimena GoldiniD· 1 shared Cecilia Arahí PratoiD· 1 shared Daiana A. CapdevilaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Ari ZeidaORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 16, 2026

Evolution of allostery without shape shifting: Internal dynamics drives functional diversification of a transcriptional repressor superfamily

Giuliano T. Antelo, Johnma J. Rondón, Matias Villarruel Dujovne…·Daiana A. Capdevila

The paper investigates how allostery evolves in the ArsR superfamily by showing that functional diversification arises from internal dynamics rather than large conformational changes.

2 citations

structural biologyproteomics

𝕏 PostBluesky

ImmunologyFrontiers in MicrobiologyPeer-reviewedMar 11, 2026

Unraveling the Dual Immunomodulatory and Immunogenic Roles of the Central Conserved Cysteine-Rich Region in Respiratory Syncytial Virus G Protein

Juan Gutman, Ana Luz Paletta, Federico Birnberg-Weiss…·Sebastián Esperante

This paper investigates how the redox state of the RSV G protein's central conserved cysteine-rich domain (CCD) influences its immunomodulatory and immunogenic properties, showing that monomeric forms suppress immune activation while oligomerization removes this effect.

1 citation

humanproteomics

𝕏 PostBluesky