Optogenetic activation of entorhinal projection neurons alters the target recognition and circuit development without enhancing axon regeneration after axotomy in organotypic slices.
Karen Wells-Cembrano, Marc Riu-Villanueva, Juan J Lopez-Jimenez, Miriam Segura-Feliu, Rosalina Gavı́n, José Antonio del Rı́o
This study uses organotypic slice cultures to show that optogenetic activation of entorhinal neurons does not enhance axon regeneration after injury but alters target recognition and circuit development.
bioRxiv · Jun 22, 2025 · PreprintNeuroscience