Rosalina Gavı́n

cis-gamma-Amino-L-proline peptides as chemical probes of amyloidogenic processing in neurons and APP/PS1 mice

This study designs and evaluates cis-gamma-amino-L-proline peptides as modulators of amyloid-beta production, showing reduced Aβ levels and improved cognition in APP/PS1 mice.

Adgrd1 deficiency reveals increased hippocampal vulnerability and selective behavioral alterations in mice

This study shows that Adgrd1 deficiency in mice leads to reduced nest-building, decreased exploratory behavior, and increased hippocampal vulnerability through molecular and circuit-level changes.

Optogenetic activation of entorhinal projection neurons alters the target recognition and circuit development without enhancing axon regeneration after axotomy in organotypic slices.

This study uses organotypic slice cultures to show that optogenetic activation of entorhinal neurons does not enhance axon regeneration after injury but alters target recognition and circuit development.

miR-519a-3p, found to regulate cellular prion protein during Alzheimer's disease pathogenesis, as a biomarker of asymptomatic stages

The paper identifies miR-519a-3p as a potential biomarker for preclinical stages of Alzheimer's disease by showing its early upregulation in AD cerebral samples.

Involvement of the cellular prion protein in seeding and spreading of sarkosyl-derived fractions of Alzheimer's disease in Prnp mutant mice and in the P301S transgenic tauopathy mice model

This study investigates the role of cellular prion protein in tau seeding and spreading using Prnp mutant mice and P301S tauopathy models, finding it significant in the latter but not in Alzheimer's sarkosyl-derived samples.