José Antonio del Rı́o

cis-gamma-Amino-L-proline peptides as chemical probes of amyloidogenic processing in neurons and APP/PS1 mice

This study designs and evaluates cis-gamma-amino-L-proline peptides as modulators of amyloid-beta production, showing reduced Aβ levels and improved cognition in APP/PS1 mice.

Adgrd1 deficiency reveals increased hippocampal vulnerability and selective behavioral alterations in mice

This study shows that Adgrd1 deficiency in mice leads to reduced nest-building, decreased exploratory behavior, and increased hippocampal vulnerability through molecular and circuit-level changes.

Optogenetic activation of entorhinal projection neurons alters the target recognition and circuit development without enhancing axon regeneration after axotomy in organotypic slices.

This study uses organotypic slice cultures to show that optogenetic activation of entorhinal neurons does not enhance axon regeneration after injury but alters target recognition and circuit development.

miR-519a-3p, found to regulate cellular prion protein during Alzheimer's disease pathogenesis, as a biomarker of asymptomatic stages

The paper identifies miR-519a-3p as a potential biomarker for preclinical stages of Alzheimer's disease by showing its early upregulation in AD cerebral samples.

Involvement of the cellular prion protein in seeding and spreading of sarkosyl-derived fractions of Alzheimer's disease in Prnp mutant mice and in the P301S transgenic tauopathy mice model

This study investigates the role of cellular prion protein in tau seeding and spreading using Prnp mutant mice and P301S tauopathy models, finding it significant in the latter but not in Alzheimer's sarkosyl-derived samples.

Genetic control of neuronal activity enhances axonal growth only on permissive substrates

The paper investigates how modulating neuronal activity with opto- or chemogenetics affects axonal growth after injury, finding that growth is enhanced only on permissive substrates.

Involvement of mechanical cues in the migration of Cajal-Retzius cells in the marginal zone during neocortical development

This study investigates how mechanical and chemical cues influence the migration of Cajal-Retzius cells in the developing neocortex, showing that mechanical properties and route stiffness affect their distribution.

Lack of p62 impairs glycogen aggregation and exacerbates pathology in a mouse model of myoclonic epilepsy of Lafora

This study shows that p62 is involved in Lafora body formation and that its absence reduces glycogen aggregation in muscle and heart but worsens brain pathology in a mouse model of Lafora disease.

Peripheral CB1 receptor blockade acts as a memory enhancer through an adrenergic-dependent mechanism

The paper shows that peripheral CB1R blockade enhances non-emotional memory through an adrenergic-dependent mechanism in mice.

Behavioral deficits, learning impairment, and enhanced hippocampal excitability in co-isogenic PrnpZH3/ZH3 mice

This study investigates the role of PrPC in hippocampal function using PrnpZH3/ZH3 mice, finding behavioral deficits, learning impairment, and increased excitability without enhanced LTP.

PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure

The paper identifies PP4-dependent HDAC3 dephosphorylation as a mechanism distinguishing axonal regeneration from regenerative failure in nerve injuries.