Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer
Yijia Hua, Ningjun Duan, Chunxiao Sun, Fan Yang, Min Tian, Yanting Sun, Shuhan Zhao, Jue Gong, Qian Liu, Xiang Huang, Yan Liang, Ziyi Fu, Wei Li, Yongmei Yin
The paper identifies SLC7A11-mediated cysteine metabolism as a target to overcome trastuzumab resistance in HER2 positive breast cancer by inducing ferroptosis.
bioRxiv · Nov 12, 2024Cancer Biology