Mitochondrial variant enrichment from high-throughput single-cell RNA-seq resolves clonal populations
Tyler E. Miller, Caleb A. Lareau, Julia A. Verga, Erica A. K. DePasquale, Vincent Liu, Daniel Ssozi, Katalin D. Sandor, Yajie Yin, Leif S. Ludwig, Chadi A. El Farran, Duncan M. Morgan, Ansuman T. Satpathy, Gabriel Kenneth Griffin, Andrew A. Lane, John Christopher Love, , Peter van Galen
The paper develops a method to detect mitochondrial mutations from single-cell RNA-seq to identify clonal expansions in human hematopoiesis.
Nature Biotechnology · Feb 24, 2022Peer-reviewedGenomics