John Christopher Love

This paper develops a nanoparticle-based method to deliver Cre mRNA for lung adenocarcinoma modeling in mice, avoiding immune activation and enabling accurate tumor-immune dynamics studies.

This study identifies lymph node resident memory T cells (LNRM) as a distinct subset with unique effector capabilities compared to lung resident memory T cells and central memory T cells.

This paper identifies molecular features of monoclonal antibodies that enhance ctDNA detection by increasing its concentration in blood.

This study shows PD-1 blockade during T cell priming promotes an intermediate-exhausted CD8 T cell state that supports durable anti-tumor immunity after surgery and metastatic challenge, better than effector or memory-like T cells.

The paper identifies GPR15+ CD38+ peripheral blood Th2 cells associated with active eosinophilic esophagitis, showing potential as a non-invasive biomarker and suggesting new disease mechanisms.

This paper uses Bayesian optimization to accelerate cell culture media development, achieving better results with fewer experiments in two applications.

This study shows that combining slow antigen delivery and follicle-targeting adjuvants enhances germinal center B cell diversity and clonal expansion in mice.

This study compares the immune response in non-human primates between alum and SMNP adjuvants, finding SMNP induces stronger humoral responses and enhanced lymph node activation.

The paper uses CRISPR-Cas9 to knock out endogenous secreted proteins in Komagataella phaffii, increasing recombinant protein production by 20x.

A DNA-binding agent increases cfDNA levels in blood, improving ctDNA detection and cancer sensitivity in mice.

A nanoparticle priming agent increases cfDNA levels in blood, improving ctDNA detection sensitivity in tumor-bearing mice.

The paper develops a method to detect mitochondrial mutations from single-cell RNA-seq to identify clonal expansions in human hematopoiesis.

This paper describes an engineered SARS-CoV-2 RBD variant that shows improved immunogenicity in mice and protective immunity in hamsters.

MAESTRO enables efficient and accurate tracking of thousands of low-frequency mutations with reduced sequencing, improving mutation testing in cancer and liquid biopsies.