Duncan M. Morgan

This study identifies a cortical niche-specific macrophage subset that drives early osteoclastogenesis in bone healing through spatial immune-stromal interactions in young mice.

This study shows PD-1 blockade during T cell priming promotes an intermediate-exhausted CD8 T cell state that supports durable anti-tumor immunity after surgery and metastatic challenge, better than effector or memory-like T cells.

The paper identifies GPR15+ CD38+ peripheral blood Th2 cells associated with active eosinophilic esophagitis, showing potential as a non-invasive biomarker and suggesting new disease mechanisms.

This study shows that ECM viscoelastic properties in bone fracture hematoma influence macrophage polarization, with high stress relaxation time promoting pro-inflammatory and low promoting anti-inflammatory responses.

This study develops a method to generate optimized peptide ligands for CAR-T cell restimulation, demonstrating enhanced expansion and memory development in preclinical models.

This study shows that combining slow antigen delivery and follicle-targeting adjuvants enhances germinal center B cell diversity and clonal expansion in mice.

The paper develops a method to detect mitochondrial mutations from single-cell RNA-seq to identify clonal expansions in human hematopoiesis.