Chadi A. El Farran

Metastatic Osteosarcoma is Characterized by Loss of Osteoblastic Lineage Fidelity

This study identifies a loss of osteoblastic lineage fidelity in metastatic osteosarcoma through single-nucleus RNA sequencing, linking it to disease progression and potential therapeutic targets.

Intratumoral gene delivery of 4-1BBL boosts IL-12-triggered anti-glioblastoma immunity

This study shows that delivering 4-1BBL via AAV enhances IL-12-induced anti-glioblastoma immunity in mouse models by boosting CD8 T cell activity and survival.

Mitochondrial variant enrichment from high-throughput single-cell RNA-seq resolves clonal populations

The paper develops a method to detect mitochondrial mutations from single-cell RNA-seq to identify clonal expansions in human hematopoiesis.

DiSCs: Domains involving SETDB1 and Cohesin are critical regulators of genome topology and stem cell fate

The paper identifies DiSCs, regions co-bound by SETDB1 and Cohesin, which regulate genome topology and stem cell fate in mouse embryonic stem cells.

Defining Essential Enhancer for Pluripotent stem cells using Features Oriented CRISPR-Cas9 Screen

The paper identifies essential enhancers for pluripotency in mouse ES cells using a CRISPR-Cas9 screen and characterizes their target genes and regulatory networks.

Diversification of Reprogramming Trajectories Revealed by Parallel Single-cell Transcriptome and Chromatin Accessibility Sequencing

This study uses scRNA-Seq and scATAC-Seq to show that human reprogramming occurs through asynchronous, diverse trajectories with distinct regulatory networks.

Parallel Bimodal Single-cell Sequencing of Transcriptome and Chromatin Accessibility

The paper introduces ASTAR-Seq, a method for parallel single-cell transcriptome and chromatin accessibility sequencing, and uses it to analyze mESCs, human cell lines, and erythroblast differentiation.