AAV-mediated peripheral single chain variable fragments administration to reduce cerebral tau in adult P301S transgenic mice: mono- vs combination therapy
Sebica Katel, Julia Cicalo, Valeria Vasciaveo, Joseph Carrión, Mahadeo Leann, Patricio T. Huerta, Philippe Marambaud, Luca Giliberto, Cristina d’Abramo
This study compares the efficacy of single-chain variable fragments (scFvs) targeting different tau epitopes in reducing cerebral tau in transgenic mice, finding that scFv-MC1 monotherapy is more effective than combination therapy.
bioRxiv · Feb 13, 2025 · PreprintNeuroscience