Philippe Marambaud

Cholinergic impairment in the dorsal motor nucleus of the vagus during experimental Alzheimer's disease

This study shows age-dependent cholinergic deficits in the dorsal motor nucleus of the vagus in experimental Alzheimer's disease, leading to impaired vagus nerve function.

Extracellular CIRP induces neurotoxic astrocytes via TREM-1 in Alzheimer's disease

This study shows eCIRP induces neurotoxic astrocytes via TREM-1 in Alzheimer's disease, with M3 blocking this effect.

Nitazoxanide activates BMP9-ALK1-SMAD signaling cascade and improves HHT vascular pathology

This study shows nitazoxanide activates BMP9-ALK1-SMAD signaling and reduces HHT vascular abnormalities by modulating mTOR activity in endothelial cells.

An angiopoietin-2 vaccine improves arteriovenous malformation pathology in hereditary hemorrhagic telangiectasia mice

A peptide vaccine targeting ANG2 reduces AVM number and size and normalizes vascular diameters in HHT mice without causing organ dysfunction.

ALK1-BMPRII agonism by clustering bispecific antibodies treats hereditary hemorrhagic telangiectasia

This study develops bispecific antibodies that activate the ALK1-BMPRII pathway, reducing AVMs and improving symptoms in HHT mouse models.

AAV-mediated peripheral single chain variable fragments administration to reduce cerebral tau in adult P301S transgenic mice: mono- vs combination therapy

This study compares the efficacy of single-chain variable fragments (scFvs) targeting different tau epitopes in reducing cerebral tau in transgenic mice, finding that scFv-MC1 monotherapy is more effective than combination therapy.

A modification-specific peptide-based immunization approach using CRM197 carrier protein: Development of a selective vaccine against pyroglutamate Aβ peptides

This paper develops a vaccine targeting pyroglutamate Aβ peptides using CRM197 carrier protein, showing it selectively induces antibodies against AβpE3 without cross-reactivity to other Aβ forms.