In Silico ModeIling of Shear Stress and Energy Dissipation Rate Effects on Human Pluripotent Stem Cell Proliferation in Vertical-Wheel Bioreactors
Ferdinand Avikpe, Faisal J. Alibhai, David A. Romero, Amirmahdi Mostofinejad, Julia E.S. Bauer, Coulter Montague, Michael A. Laflamme, Cristina H. Amon
This study develops and validates a mathematical model to predict hPSC proliferation in vertical-wheel bioreactors by incorporating shear stress and energy dissipation rate effects, achieving accurate predictions with low error rates.
bioRxiv · Apr 26, 2026 · PreprintBioengineering