Hierarchical cysteine oxidation controls reversible amyloid formation in an ankyrin repeat protein
Aakriti Sethi, Hannah Darroch, Nicholas J. Magon, Grant Greene, Karina M. O'Connor, Alex D. Botha, Shelby G. Gray, Pierre de Cordovez, Rachel Coldicott, Julia Horsfield, Vanessa K. Morris, Christoph Göbl
This paper shows that cysteine oxidation in drP18 controls reversible amyloid formation, with distinct oxidants leading to different amyloid kinetics and morphologies.
bioRxiv · Sep 3, 2026 · PreprintBiochemistry