An epigenetic bifunctional that toggles between transactivation and repression
Ananthan Sadagopan, Maximilian Carson, Eriks J. Zamurs, Shanivi Srikonda, Cary N. Weiss, Michael J. Bond, Anurag Sodhi, Katherine A. Donovan, Julia K Ryan, Eric S. Fischer, Kimberly Stegmaier, Srinivas Raghavan Viswanathan, Benjamin L. Ebert, William J. Gibson
This paper identifies a bifunctional small molecule that can induce both transactivation and repression of gene expression depending on cellular context.
bioRxiv · Mar 20, 2026 · PreprintBiochemistry