Unleashed condensation by recurrent mutations of an epigenetic regulator promotes cancer
Yansu Song, Yi Hao, Maria Latacz, Marta Cykowiak, Julia Kirylczuk, Xuebo Quan, Francesco Palomba, Songwei Ni, Linjie Liu, Jing Hu, Bi Shi, Ammon E. Posey, Qiaoli Li, Haoran Yuan, Jie Sun, , Hao Jiang
This study shows that ASXL1 mutations promote cancer by unleashing phase separation, which enhances gene activation and leukemogenesis.
bioRxiv · Feb 20, 2026 · PreprintBiochemistry