Kai Huang

This study shows that ASXL1 mutations promote cancer by unleashing phase separation, which enhances gene activation and leukemogenesis.

This study investigates how SMC complexes interact during mitosis to shape 3D genome structure by engineering cohesin/condensin configurations on mitotic chromosomes.

The paper reveals power law residence scaling in both passive and active liquids, showing sensitivity to liquid environment and suggesting active phase separation as a scaling proofreading mechanism in gene regulation.

The paper introduces ChromSTEM, a method for high-resolution 3D imaging of chromatin structure, and finds that chromatin forms well-defined domains around 100 nm in radius with radially decreasing mass-density.

The paper introduces a nano-ChIA platform that combines electron tomography and superresolution imaging to study chromatin structure and dynamics at the single-nucleosome level in live cells.

The paper proposes a self-returning random walk model to explain interphase chromatin structure, reconciling high contact frequency and structural heterogeneity.