Spatially resolved tumor-microenvironment architecture defines therapeutic response in unresectable hepatoblastoma
Zahra Mesrizadeh, Mylarappa Ningappa, Sarangarajan Ranganathan, Kavitha Mukund, Catherine Gestrich, Julia Meade, Judy Hereford Squires, Lori A. Schmitt, George Vincent Mazariegos, Marcus Malek, Chethan Ashokkumar, William A. MacDonald, Paul Morgan, Shankar Subramaniam, Rakesh Sindhi
This study identifies spatial tumor-microenvironment architectures in hepatoblastoma that correlate with therapeutic response using spatial transcriptomics and single-cell imaging.
bioRxiv · Oct 13, 2026 · PreprintCancer Biology