Author

Lori A. Schmitt

Children's Hospital of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Chethan AshokkumariD· 3 shared George Vincent MazariegosiD· 3 shared Mylarappa NingappaiD· 3 shared Shankar SubramaniamiD· 3 shared Brandon W. HiggsiD· 2 shared Rakesh K. SindhiiD· 2 shared Sarangarajan RanganathaniD· 2 shared Adriana ZeeviiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

Chethan AshokkumarORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Spatially resolved tumor-microenvironment architecture defines therapeutic response in unresectable hepatoblastoma

Zahra Mesrizadeh, Mylarappa Ningappa, Sarangarajan Ranganathan, Kavitha Mukund, Catherine Gestrich, Julia Meade, Judy Hereford Squires, Lori A. Schmitt, George Vincent Mazariegos, Marcus Malek, Chethan Ashokkumar, William A. MacDonald, Paul Morgan, Shankar Subramaniam, Rakesh Sindhi

This study identifies spatial tumor-microenvironment architectures in hepatoblastoma that correlate with therapeutic response using spatial transcriptomics and single-cell imaging.

bioRxiv · Oct 13, 2026 · PreprintCancer Biology

Spatial landscape of pretransplant liver disease and post-transplant immune outcomes in children

Chris Kang, Mylarappa Ningappa, Brandon W. Higgs, Catherine K. Gestrich, George Vincent Mazariegos, Chethan Ashokkumar, Lori A. Schmitt, Sarangarajan Ranganathan, Shankar Subramaniam, Rakesh K. Sindhi

The paper analyzes spatial molecular patterns in liver disease and transplant outcomes using single-cell RNA sequencing data from multiple conditions and post-transplant biopsies.

bioRxiv · Oct 2, 2026 · PreprintGenomics

Liver transplant rejection features memory cell priming, spatially differentiated networks and novel drug targets.

Mylarappa Ningappa, Chethan Ashokkumar, Divya Murali, Dhivyaa Rajasundaram, Brandon W. Higgs, William McDonald, Lori A. Schmitt, Liang Zhang, Ansuman Chattopadhyay, Matt Kane, Patrick Murphy, Kyle A Soltys, George Vincent Mazariegos, Shakti Gupta, Upendra K. Kar, , Rakesh K. Sindhi

The paper identifies molecular and spatial features of early liver transplant rejection, including primed T-cells, immune synapse activation, and novel drug targets like proteasomal and HSP90 inhibitors.

bioRxiv · Feb 4, 2025 · PreprintImmunology