George Vincent Mazariegos

This study identifies spatial tumor-microenvironment architectures in hepatoblastoma that correlate with therapeutic response using spatial transcriptomics and single-cell imaging.

The paper analyzes spatial molecular patterns in liver disease and transplant outcomes using single-cell RNA sequencing data from multiple conditions and post-transplant biopsies.

The paper identifies molecular and spatial features of early liver transplant rejection, including primed T-cells, immune synapse activation, and novel drug targets like proteasomal and HSP90 inhibitors.