Sarangarajan Ranganathan

This study identifies spatial tumor-microenvironment architectures in hepatoblastoma that correlate with therapeutic response using spatial transcriptomics and single-cell imaging.

The paper analyzes spatial molecular patterns in liver disease and transplant outcomes using single-cell RNA sequencing data from multiple conditions and post-transplant biopsies.

This paper describes the generation of genetically-defined murine hepatoblastoma cell lines with angiogenic potential and reports their tumorigenic properties and drug sensitivities.

This paper describes the generation of isogenic murine hepatoblastoma cell lines with defined oncogenic drivers, which retain tumorigenicity and express endothelial markers under hypoxic conditions.

This study defines the transcriptional landscape of CD8+ T cells in pediatric liver transplant rejection using single-cell sequencing and identifies persistent CD8+ clones associated with graft failure.

This study identifies EZH2 as an oncogenic driver in hepatoblastoma, showing its role in promoting tumor progression through epigenetic silencing and noncanonical signaling, and highlights its potential as a therapeutic target.

The paper identifies Gas1 as a suppressor of hepatoblastoma tumorigenesis by showing its restoration inhibits tumor growth in mice and cell lines, and identifies a common set of B-Y-N regulated genes.