A highly dynamic active state for transducin-bound phosphodiesterase-6 in vertebrate phototransduction
Jessica N Holechek, Julia Y Shang, Tufa E. Assafa, Brian R. Crane, Richard A. Cerione
This paper uses biophysical techniques to show that GT* binding to PDE6 induces a dynamic active state, revealing a previously unobserved conformation associated with catalysis.
bioRxiv · Jul 30, 2026 · PreprintBiochemistry