Author

Jessica N Holechek

Cornell UniversityORCID 0000-0002-9449-1706Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Brian R. CraneiD· 1 shared Julia Y Shang· 1 shared Richard A. CerioneiD· 1 shared Tufa E. AssafaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

Brian R. CraneORCID

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1 paper

Recent·Most cited

A highly dynamic active state for transducin-bound phosphodiesterase-6 in vertebrate phototransduction

Jessica N Holechek, Julia Y Shang, Tufa E. Assafa, Brian R. Crane, Richard A. Cerione

This paper uses biophysical techniques to show that GT* binding to PDE6 induces a dynamic active state, revealing a previously unobserved conformation associated with catalysis.

bioRxiv · Jul 30, 2026 · PreprintBiochemistry