Richard A. Cerione

This study identifies Survivin as a critical KRAS signaling partner that promotes glycolytic activity in PDAC cells by forming microtubule-based complexes with glycolytic enzymes.

This paper uses biophysical techniques to show that GT* binding to PDE6 induces a dynamic active state, revealing a previously unobserved conformation associated with catalysis.

This study identifies SIRT2 as a regulator of translation by deacetylating and stabilizing 4EBP1, which suppresses protein synthesis under amino acid limitation.

This study examines two GLS mutants causing neurological disease, finding they lose glutamate inhibition and phosphate dependency, leading to glutamate accumulation and disrupted homeostasis.

This study uses multi-temperature X-ray crystallography to reveal temperature-dependent conformational changes in K-RAS, identifying new druggable sites and highlighting the limitations of cryogenic conditions in capturing dynamic states.

This paper investigates the conformational states of TG2 and shows how an inhibitor stabilizes an open conformation that is cytotoxic to cancer cells.

The paper shows that inhibiting glutaminase enzymes blocks coronavirus replication in mammalian cells, suggesting these inhibitors as potential anti-viral drugs.