Tufa E. Assafa

This paper uses biophysical techniques to show that GT* binding to PDE6 induces a dynamic active state, revealing a previously unobserved conformation associated with catalysis.

This study identifies structural features determining G protein coupling specificity at a class A GPCR using a Gi-biased agonist.

This study investigates the multi-state kinetics of Tc toxin prepore-to-pore transition, identifying intermediate states and transition times under various conditions.

This study shows that N-linked glycans on PrPC are essential for maintaining a non-toxic structure and suppressing neurotoxicity through intramolecular interactions.