βPix sequesters IDOL and prevents LDL receptor degradation through a β2AR-regulated signaling pathway in Alport Syndrome
Ahmed Chahdi, Keyvan Yousefi, José Manuel Cóndor Capcha, Camila Iansen Irion, Guerline Lambert, Serene A. Shehadeh, Julian C. Dunkley, Yee‐Shuan Lee, Aisha Khan, Melina Ramic, Nadja S. Andrade, Zane R. Zeier, Derek Michael Dykxhoorn, Chryso Pefkaros Katsoufis, Michael Freundlich, , Lina A. Shehadeh
This study identifies βPix as a regulator of LDLR stability by sequestering IDOL, preventing LDLR degradation, and reducing LDL-C uptake in Alport Syndrome models.
bioRxiv · Nov 6, 2020 · PreprintMolecular Biology