Author

Melina Ramic

University of Miami

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Nadja S. Andrade· 2 shared Zane R. ZeieriD· 2 shared Abbas Abdallah· 1 shared Ahmed ChahdiiD· 1 shared Aisha KhaniD· 1 shared Alireza EdrakiiD· 1 shared Anastasios LymperopoulosiD· 1 shared Aydan KahrimaniD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

Nadja S. Andrade

Mutual co-authors in cluster

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2 papers

Recent·Most cited

CRISPR/Cas9-Mediated Excision of ALS/FTD-Causing Hexanucleotide Repeat Expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro

Katharina E. Meijboom, Abbas Abdallah, Nicholas P. Fordham, Hiroko Nagase, Tomás Rodríguez, Carolyn Kraus, Tania F. Gendron, Gopinath Krishnan, Rustam Esanov, Nadja S. Andrade, Matthew J. Rybin, Melina Ramic, Zachary D. Stephens, Alireza Edraki, Meghan Blackwood, , Christian Mueller

This study removes a hexanucleotide repeat expansion in C9ORF72 using CRISPR/Cas9 in cell and animal models, reducing disease hallmarks.

Nature Communications · Oct 21, 2022Peer-reviewedMolecular Biology

βPix sequesters IDOL and prevents LDL receptor degradation through a β2AR-regulated signaling pathway in Alport Syndrome

Ahmed Chahdi, Keyvan Yousefi, José Manuel Cóndor Capcha, Camila Iansen Irion, Guerline Lambert, Serene A. Shehadeh, Julian C. Dunkley, Yee‐Shuan Lee, Aisha Khan, Melina Ramic, Nadja S. Andrade, Zane R. Zeier, Derek Michael Dykxhoorn, Chryso Pefkaros Katsoufis, Michael Freundlich, , Lina A. Shehadeh

This study identifies βPix as a regulator of LDLR stability by sequestering IDOL, preventing LDLR degradation, and reducing LDL-C uptake in Alport Syndrome models.

bioRxiv · Nov 6, 2020 · PreprintMolecular Biology