Stereoselective Covalent Targeting of BTK(C481S) and Kinases with β-Lactone Electrophiles
Celine D. Wang, Polina E Barzova, Julian Robles, Ethan S. Toriki, F. García, Jeffrey M. McKenna, Markus Schirle, Ziyang Zhang
This paper develops stereoselective β-lactone electrophiles to covalently target BTK(C481S) and other kinases, showing enantiomers engage distinct kinome subsets.
bioRxiv · Jul 6, 2026 · PreprintBiochemistry