Stereoselective Covalent Targeting of BTK(C481S) and Kinases with β-Lactone Electrophiles
Celine D. Wang, Polina E Barzova, Julian Robles…·Ziyang Zhang
This paper develops stereoselective β-lactone electrophiles to covalently target BTK(C481S) and other kinases, showing enantiomers engage distinct kinome subsets.