Ziyang Zhang

This study identifies ITPKB as a regulator of NK cell desensitization, showing its inhibition enhances antitumor immunity in murine and human models.

This paper develops stereoselective β-lactone electrophiles to covalently target BTK(C481S) and other kinases, showing enantiomers engage distinct kinome subsets.

The paper identifies small molecules that enhance GTP hydrolysis in K-Ras Q61 mutants, reducing GTP-bound Ras and downstream signaling.

The paper investigates acute rapamycin treatment in a maternal inflammation mouse model of autism, showing rapid rescue of behavioral and functional dysfunctions linked to mTOR pathway activation.

This study demonstrates that dual drug administration of RapaLink-1 and RapaBlock selectively inhibits mTORC1 in the brain while protecting it in the periphery, reducing side effects and moderating alcohol use in mice.

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.