TCF4 and CtBP1 Repress LEF1 to Maintain a TCF4-centric Transcriptional Program in Colon Cancer.
Markus A. Brown, Sanam Yaghoubi, Juliane Kamlah, Wei-dong D. Chen, Darawalee Zong, Sepehr Talebian Khorasani, Tianzuo Zhan, Michael Boutros, Jordi Camps, Paul S. Meltzer
This study shows TCF4 represses LEF1 to maintain a TCF4-driven transcriptional program in colon cancer, with TCF4 regulating MYC and cell cycle while repressing LEF1's immune-related effects.
bioRxiv · Sep 28, 2026 · PreprintCell Biology