Tianzuo Zhan

This study shows TCF4 represses LEF1 to maintain a TCF4-driven transcriptional program in colon cancer, with TCF4 regulating MYC and cell cycle while repressing LEF1's immune-related effects.

The paper identifies a fetal-like stem cell trajectory in colorectal cancer using multi-omics and organoid models, linked to poor prognosis and SRC/mTOR dependency.

The paper uses a patient-derived rectal cancer organoid platform to identify MEK and PARP inhibitors that synergize with radiation to enhance treatment response in locally advanced rectal cancer.

This study shows MEK1/2 inhibitors reduce AXIN1 levels in CRC by mTOR-dependent translational repression, not by affecting protein stability.

This study uses image-based profiling and multi-omics integration to identify morphological axes of variation in colorectal cancer organoids and link them to biological mechanisms and drug responses.

CRISPRAnalyzeR is a web application that unifies eight hit-calling methods and 26 external annotation resources to analyze, visualize, and document pooled CRISPR/Cas9 screens without requiring bioinformatics expertise.