Author

Markus A. Brown

University of Maryland, College ParkORCID 0000-0002-2069-0120Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Anthony M. BlochiD· 1 shared Darawalee Zong· 1 shared Geoff Patterson· 1 shared Haiming CheniD· 1 shared Huijing XueiD· 1 shared Indika RajapakseiD· 1 shared Jordi CampsiD· 1 shared Juliane Kamlah· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBioinformatics

Anthony M. BlochORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 28, 2026

TCF4 and CtBP1 Repress LEF1 to Maintain a TCF4-centric Transcriptional Program in Colon Cancer.

Markus A. Brown, Sanam Yaghoubi, Juliane Kamlah…·Paul S. Meltzer

This study shows TCF4 represses LEF1 to maintain a TCF4-driven transcriptional program in colon cancer, with TCF4 regulating MYC and cell cycle while repressing LEF1's immune-related effects.

DOI 10.64898/2026.09.25.751839

humanbulk RNA-seq

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Developmental BiologyInternational Journal of Molecular SciencesPeer-reviewedMay 14, 2022

Impaired Lef1 activation accelerates iPSC-derived keratinocytes differentiation in Progeria

Xiaojing Mao, Zheng‐Mei Xiong, Huijing Xue…·Kan Cao

This study shows that impaired Lef1 activation in HGPS iPSCs accelerates keratinocyte differentiation, and base editing partially rescues this phenotype.

7 citations

humanbulk RNA-seq

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BioinformaticsProceedings of the National Academy of SciencesPeer-reviewedOct 24, 2017

An Algorithm for Cellular Reprogramming

Scott Ronquist, Geoff Patterson, Lindsey A. Muir…·Indika Rajapakse

The paper introduces a data-guided algorithm for cellular reprogramming using transcription factors, validated on human fibroblasts and showing potential for tissue regeneration and cancer cell reprogramming.

40 citations

humanbulk RNA-seq

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