Melanin-concentrating hormone signaling regulates persistence and updating of reward-guided actions
Pratheba Kandasamey, Cristina Concetti, JULIE BURKHARDT, Edward F. Bracey, Denis Burdakov, Daria Peleg‐Raibstein
This study shows that MCH signaling influences how reward-guided behavior persists or updates when contingencies change, with MCHR1 blockade reducing perseveration and speeding adaptation.
bioRxiv · Aug 20, 2026 · PreprintNeuroscience