Edward F. Bracey

The paper identifies two separable neurochemical axes—orexin-driven arousal and dopamine-mediated utility—that govern task engagement in mice, with implications for drug effects and motivation disorders.

The paper identifies a neural circuit involving hypocretin/orexin neurons that rapidly suppresses hunger through a GABAergic relay, enabling dynamic regulation of hunger based on arousal.

This study investigates how the MCH system influences persistence and adaptive updating in reward-guided behavior using touchscreen tasks in rodents.

This study shows that MCH signaling influences how reward-guided behavior persists or updates when contingencies change, with MCHR1 blockade reducing perseveration and speeding adaptation.

This study shows that blocking MCHR1 receptors in the prefrontal cortex helps mice stop responding to outdated warning signals while maintaining their ability to learn from danger.

The paper identifies orexin/hypocretin neurons as precise encoders of net body movement across behaviors and metabolic states, independent of head movement and nutritional state.

The paper investigates how hypothalamic hypocretin/orexin neurons regulate decision policy complexity through metabolic and neural signaling mechanisms in mice.

This study identifies a link between hypothalamic orexin neuron activity and seizures in a mouse model and shows that targeting this activity with deep brain stimulation can reduce seizures.

This study investigates the roles of NAc D1 and D2 cells in hedonic eating by analyzing their contributions to liking and wanting, revealing distinct functions in food choice and overconsumption.

This study investigates the role of hypothalamic orexin neurons in controlling pupil size, linking their activity to arousal and reward states through specific stimulation and in vivo recordings.

This study shows that orexin neurons decode blood glucose dynamics to drive adaptive behavior in mice by tracking glucose gradients and generating neural adaptations.

The paper investigates whether hypocretin/orexin neurons track sensory, cognitive, or motor information by analyzing their activity during sound cues and reward outcomes.

This study identifies that vestibular inputs dominate angular head velocity coding in the retrosplenial cortex, while visual input enhances its accuracy during navigation.

This study shows orexin/hypocretin neurons rapidly control movement by integrating sensory input and initiating locomotion.