Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins
Timothy Hoggard, FuJung Chang, Kelsey Rae Perry, Sandya Subramanian, Jessica Kenworthy, Julie Chueng, Erika Shor, Michael S. Cosgrove, Jef D. Boeke, Catherine A. Fox, Michael Alexander Weinreich
The paper shows that yeast heterochromatin regulators Sir2 and Sir3 directly affect euchromatic DNA replication origins by modifying chromatin structure and suppressing MCM loading defects.
PLoS Genetics · May 24, 2018Peer-reviewedGenetics