Catherine A. Fox

The paper investigates the role of the Fkh1 FHA domain in promoting early S-phase DNA replication origins and inhibiting late origins by modulating chromatin structure and ORC-origin interactions.

The paper investigates RNA target-site recognition by Bicc1 proteins across species, showing conserved and diverged mechanisms involving KH domains.

This study identifies the FHA domain of Fkh1 as a factor that enhances ORC binding to a subset of DNA replication origins in budding yeast by interacting with specific DNA sequences.

The paper shows Sir2 regulates MCM complex distribution in yeast chromosomes to ensure proper origin licensing and genome duplication.

This study uses a Drosophila model to show that a Meier-Gorlin Syndrome mutation in Orc4 causes tissue-specific DNA replication defects, particularly affecting female fertility.

The paper shows that yeast heterochromatin regulators Sir2 and Sir3 directly affect euchromatic DNA replication origins by modifying chromatin structure and suppressing MCM loading defects.