Timothy Hoggard

This study identifies SPINK1 as a regulator of epigenomic states and stemness in PDAC through its interaction with COL18A1 and endostatin release.

The paper investigates the role of the Fkh1 FHA domain in promoting early S-phase DNA replication origins and inhibiting late origins by modulating chromatin structure and ORC-origin interactions.

This study identifies the FHA domain of Fkh1 as a factor that enhances ORC binding to a subset of DNA replication origins in budding yeast by interacting with specific DNA sequences.

The paper shows Sir2 regulates MCM complex distribution in yeast chromosomes to ensure proper origin licensing and genome duplication.

The paper shows that yeast heterochromatin regulators Sir2 and Sir3 directly affect euchromatic DNA replication origins by modifying chromatin structure and suppressing MCM loading defects.