Dissecting mechanisms of human islet differentiation and maturation through epigenome profiling
Juan R. Alvarez‐Dominguez, Julie Donaghey, Niloofar Rasouli, Jennifer Hyoje-Ryu Kenty, Aharon Helman, Jocelyn Charlton, Juerg Straubhaar, Alexander Meissner, Douglas A. Melton
This study profiles the epigenome during human islet differentiation, revealing epigenetic priming of lineage-defining loci and the role of LMX1B in endocrine progenitor regulation.
Cell stem cell · Dec 12, 2019Peer-reviewedGenomics