Alexander Meissner

This study identifies CHKA/PAF metabolic dependency in clonal hematopoiesis across multiple mutations and shows its suppression reduces clonal expansion.

This study investigates the relationship between age-related epigenetic changes in DNA methylation, chromatin accessibility, and histone modifications across human aging using integrated WGBS and ATAC-seq data.

This study uses multimodal single-cell analysis to identify transcription factor networks involved in T-cell aging.

This study uses temporal PRC2 degradation in embryoid models to reveal lineage-specific gene expression changes and the role of transcription factors in PRC2 loss responses.

This study shows PD-1 blockade during T cell priming promotes an intermediate-exhausted CD8 T cell state that supports durable anti-tumor immunity after surgery and metastatic challenge, better than effector or memory-like T cells.

This study shows human brain organoids can mature over 5 years in culture, transcriptionally aging and retaining memory of time spent in vitro.

SpinePy provides a framework for 3D spatiotemporal quantification of multicellular systems by aligning data to dynamic internal coordinate systems, revealing patterning classes influenced by gastruloid volume.

This study uses CRUDO to show that cohesin and 3D contacts influence enhancer-promoter regulation, with distal enhancers showing stronger cohesin dependence.

The study compares reprogramming methods for 16p11.2 deletion patient iPSCs and finds no significant differences in their differentiation potential into functional neurons.

The paper identifies and characterizes LNCSOX17, a lncRNA essential for human endoderm formation, showing its role in regulating transcriptome and differentiation.

The paper shows hypoxia induces an early primitive streak signature in ES cells, enhancing gastruloid elongation and lineage representation through Hif1-mediated transcriptional changes.

This study identifies GATA transcription factors as essential for initiating Xist upregulation and X-chromosome inactivation in mouse embryos through direct activation of a distal enhancer.

The paper generates a chromosome-level genome assembly for the functionally extinct northern white rhinoceros and compares it to the southern white rhinoceros.

The paper identifies a point of irreversible commitment in granulocytic differentiation and shows how chromatin state dynamics and transcription factor feedback loops influence this decision.

The paper shows that divergent gene expression within TADs is resolved through TAD restructuring and DNA methylation, not enhancer-promoter compatibility or position.

This study investigates epigenetic mechanisms in mammals, revealing distinct roles of DNA methylation and Polycomb group repressors in autosomal imprinting and identifying unique pathways in the extraembryonic ectoderm.

This study investigates the emergence and patterning dynamics of mouse definitive endoderm using in vivo and in vitro models, revealing self-sorting and Sox17 expression patterns.

The paper describes a method to generate trunk-like structures from mouse embryonic stem cells that mimic embryonic development features.

This study identifies temporally divergent regulatory mechanisms in neuronal development and maturation across mouse and marmoset neocortex.

The paper identifies extensive methylation changes in genes related to facial and vocal anatomy in modern humans compared to ancient humans and chimpanzees.

This study profiles the epigenome during human islet differentiation, revealing epigenetic priming of lineage-defining loci and the role of LMX1B in endocrine progenitor regulation.

This study shows that Firre and Dxz4 deletions in mice affect autosomal gene regulation without impacting XCI.

The paper develops a molecular recorder to track lineage and define a mouse cell fate map using scRNA-seq, revealing transcriptional convergence of endodermal cells and estimating progenitor cell numbers.

This study identifies tau pathology-driven chromatin organization changes in aged human brains and shows these effects can be reversed with HSP90 inhibitors.

This paper develops a Cas12a-based enrichment strategy and algorithm for nanopore sequencing to quantify repeat expansions and their methylation status.

The paper analyzes MYOD-mediated reprogramming of human fibroblasts using single-cell RNA-Seq to identify molecular determinants of reprogramming success and failure.