Ral GTPases promote metastasis by controlling biogenesis and organ colonization of exosomes
Shima Ghoroghi, Benjamin Mary, Annabel Larnicol, Annick Klein, Nael Osmani, Ignacio Busnelli, Francois Delalande, Nicodeme Paul, Sebastien Halary, Frederic Gros, Laetitia Fouillen, Anne-Marie Haeberle, Cathy Royer, Coralie Spiegelhalter, Gwennan Andre-Gregoire, , Vincent Hyenne
This study shows Ral GTPases regulate exosome biogenesis and organ colonization, promoting metastasis through MCAM/CD146 modulation in breast cancer.
bioRxiv · Jul 10, 2020 · PreprintCancer Biology