Vincent Hyenne

This study shows that therapeutic poxviruses induce the secretion of immunostimulating and anti-tumoral extracellular vesicles, which can reduce tumor growth in mice.

The paper introduces a semi-automated image analysis pipeline to quantify lysosome positioning in melanoma cells using ImageJ and CellProfiler.

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

This paper develops RalA-specific intrabodies that inhibit mitochondrial fission and extracellular vesicle secretion, reducing metastasis in a TNBC mouse model.

This study shows that depleting all platelet integrins in mice increases bleeding time, impairs arterial thrombosis, and reduces tumor growth and metastasis.

This study evaluates IO STMS nanocomposites in a zebrafish metastasis model, showing they inhibit metastatic outgrowth regardless of drug loading and improve embryo survival with increased HSA coating.

This study shows mechanical stress increases EV release from cancer cells via caveolin-1, leading to more tumorigenic EVs that promote metastasis.

This study shows Ral GTPases regulate exosome biogenesis and organ colonization, promoting metastasis through MCAM/CD146 modulation in breast cancer.