Author

Ignacio Busnelli

Inserm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Annabel LarnicoliD· 2 shared Jacky G. GoetziD· 2 shared Vincent HyenneiD· 2 shared Anne-Marie Haeberle· 1 shared Annick Klein· 1 shared Benjamin Mary· 1 shared Cathy Royer· 1 shared Charlotte SarreiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Annabel LarnicolORCID

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Author profile →

2 papers

Recent·Most cited

Selective targeting of RalA with intrabodies impairs Triple Negative Breast Cancer metastasis

Charlotte Sarre, Kateřina Jeřábková, Vincent Denis, Giulia Bertolin, Marc Tramier, Louis Bochler, Cristina Liboni, Ignacio Busnelli, Quentin Frenger, Annabel Larnicol, Frédéric Gros, Olivier Lefèbvre, Laurence Guglielmi, Jacky G. Goetz, Vincent Hyenne, Pierre Martineau

This paper develops RalA-specific intrabodies that inhibit mitochondrial fission and extracellular vesicle secretion, reducing metastasis in a TNBC mouse model.

bioRxiv · Jan 9, 2026 · PreprintCancer Biology

Ral GTPases promote metastasis by controlling biogenesis and organ colonization of exosomes

Shima Ghoroghi, Benjamin Mary, Annabel Larnicol, Annick Klein, Nael Osmani, Ignacio Busnelli, Francois Delalande, Nicodeme Paul, Sebastien Halary, Frederic Gros, Laetitia Fouillen, Anne-Marie Haeberle, Cathy Royer, Coralie Spiegelhalter, Gwennan Andre-Gregoire, , Vincent Hyenne

This study shows Ral GTPases regulate exosome biogenesis and organ colonization, promoting metastasis through MCAM/CD146 modulation in breast cancer.

bioRxiv · Jul 10, 2020 · PreprintCancer Biology